Phenotyping Exertional Breathlessness Using Cardiopulmonary Cycle Exercise Testing in People With Chronic Airflow Limitation.

ABSTRACT:

Background

Exertional breathlessness is a cardinal symptom of people with chronic airflow limitation (CAL) and can be evaluated using cardiopulmonary exercise testing (CPET).

Research question

Does abnormally high exertional breathlessness in relationship to the rate of oxygen uptake (V'O₂) and minute ventilation (V'_E) indicate different underlying pathophysiologic mechanisms and clinical characteristics in people with CAL?

Study design and methods

Analysis of people aged ≥ 40 years with CAL (FEV₁ to FVC ratio after bronchodilation less than lower limit of normal) undergoing symptom-limited incremental cycle CPET in the Canadian Cohort Obstructive Lung Disease study. Using published normative references, breathlessness phenotypes at pe

SUBMITTER: Ekstrom M 

PROVIDER: S-EPMC12405935 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature