Long telomere inheritance through budding yeast sexual cycles.

ABSTRACT: The ends of linear eukaryotic chromosomes are protected from being recognized as DNA double-strand breaks by telomeres, containing repetitive DNA sequences that bind specific proteins. In humans, mutations in telomere regulatory genes lead to short or long telomere syndromes. These syndromes often show genetic anticipation, where the disease has an earlier onset and a more severe manifestation in each new generation. Later generations inherit not only the mutation affecting telomere length, but also abnormal telomere length. Many aspects of telomere length homeostasis are conserved between mammals and yeast. Here, we explored telomere length inheritance patterns through the sexual cycle in yeast. Analysis of single telomeres, rather than bulk telomeres, shows that if haploid yeast with sho

SUBMITTER: Sidarava V 

PROVIDER: S-EPMC12406008 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature