Flavonoids in <i>Rosa roxburghii</i> Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1-Mediated Epigenetic Modulation.

ABSTRACT: Obesity-related complications are often driven by chronic inflammation and oxidative stress, exacerbated by aberrant DNA methylation. Natural products with anti-inflammatory and antioxidant properties may offer therapeutic potential. This study investigated the potential molecular mechanisms underlying the effects of Rosa roxburghii Tratt fermentation broth (RRTFB) on obesity through targeted methylation, while also examining its primary active components and assessing its potential therapeutic value. Male SD rats were fed a high-fat diet (HFD) to induce obesity, with RRTFB administered as an intervention. Various methods, including reduced representation bisulfite sequencing analysis (RRBS), molecular docking, surface plasmon resonance (SPR), and other analytical methods were emplo

SUBMITTER: Liu M 

PROVIDER: S-EPMC12406086 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature