Perilla Seed Hulls Polyphenol Extract: Molecular Characterization and Suppression of LPS-Induced Inflammation in RAW 264.7 Cells via NF-κB Signaling Pathway.

ABSTRACT: As a dual-purpose medicinal and edible resource, Perilla seeds are rich in bioactive compounds. There are very few studies on the by-product of perilla seed hells. Moreover, there is a lack of systematic research on the chemical composition and biological activity of perilla seed hell polyphenols. We employed ultrasound-assisted extraction (60% ethanol, 410 W power, 30 min, liquid-solid ratio 30:1 mL/g) to obtain polyphenols from PSH, yielding perilla seed hulls polyphenol crude extraction (PSH-C), and further verified the presence of polyphenolic compounds using Fourier transform infrared spectroscopy (FT-IR). Subsequently, PSH-C was further separated and purified using HPD600 macroporous resin to obtain a purified perilla seed hulls polyphenol extract (PSH-P). The polyphenolic compositio

SUBMITTER: Xie D 

PROVIDER: S-EPMC12406173 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature