Predictors of Acute HCV Incidence in People with HIV: Insights from a Long-term Cohort Study.

ABSTRACT:

Background

Persons living with HIV (PWH) remain at risk for hepatitis C virus (HCV) acquisition despite antiretroviral therapy, particularly among those who inject drugs or engage in high-risk sexual behaviors. We evaluated acute HCV incidence and associated risk factors in PWH, incorporating sex-specific differences and the use of Nucleic Acid Testing (NAT) methods, which were not addressed in previous analyses.

Methods

We assessed NAT-based HCV incidence from 1996-2011 in the ACTG ALLRT cohort, a long-term study of PWH after initiating antiretroviral therapy. Multivariable Poisson regression identified associations with self-reported injection drug use (IDU), and time-varying CD4+ count, HIV RNA level and increased ALT (grade ≥3). No sexual risk factors or non-IDU drug use

SUBMITTER: Chaillon A 

PROVIDER: S-EPMC12406231 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature