The More the Better?─Vitamin E TPGS as a Release Enhancer for Ritonavir/PVPVA Amorphous Solid Dispersions.

ABSTRACT: Amorphous solid dispersions (ASDs) are state-of-the-art formulation strategies for improving the solubility and release of poorly water-soluble, small-molecule active pharmaceutical ingredients (APIs). However, high drug loads (DLs) in ASDs can lead to phase-separation phenomena, resulting in eventually incomplete/collapsed API release, classically referred to as loss of release. This study investigates the role of the surfactant d-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) in mitigating this phenomenon in ASDs composed of ritonavir and poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA). As part of the investigations, we developed an improved sampling protocol to differentiate between ASD components molecularly dissolved and those released as nano droplets into the aqueous me

SUBMITTER: Fahrig I 

PROVIDER: S-EPMC12406244 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature