Nitric Oxide-Releasing Microparticles: A Novel Treatment for Onychomycosis.

ABSTRACT: Onychomycosis is one of the most prevalent fungal infections worldwide, resulting in negative effects on general quality of life. Management of the disease encounters a series of obstacles, and antifungal treatment has a low success rate. We aimed to develop and evaluate a novel formulation of NO-releasing microparticles (SNO-MPs) against some of the most common causative agents of onychomycosis: Trichophyton mentagrophytes, Trichophyton rubrum, Candida albicans, and Aspergillus flavus. SNO-MP susceptibility testing was performed in vitro, and MICs and MFCs were established for multiple strains. SNO-MP was also tested ex vivo in human nail fragments, with biofilm formation and biofilm disruption assessed using scanning electron microscopy and colon

SUBMITTER: Valdez AF 

PROVIDER: S-EPMC12406251 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature