MMP-Sensitive Macrophage-Targeted Coenzyme Q10 Nanomedicine for Rheumatoid Arthritis Treatment.

ABSTRACT: In this work, a novel nanoparticle (NP)-based formulation (i.e., nanomedicine) was developed to specifically deliver coenzyme Q10 (CoQ10) to macrophages for treating rheumatoid arthritis (RA). The NPs containing the matrix metalloproteinase (MMP)-responsive polymer, polyethylene glycol-peptide-phosphatidylethanolamine (PEG-pp-PE), and phosphatidylserine were designed, in which the NPs' PEG "corona" decreased nonspecific interaction, and the overexpressed MMP-2/9 in the inflamed synovium triggered PEG deshielding and PS-mediated phagocytosis. The NPs were prepared by a thin-film hydration method, and their particle size, zeta potential, drug loading, and drug release were determined. CoQ10 could be loaded into the NPs with a drug loading of about 9.7% at the polymer/PS ratio of 50:50. The C

SUBMITTER: Akram A 

PROVIDER: S-EPMC12406254 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature