Food Additives Inhibit Intestinal Drug Transporters but Have Limited Effect on In Vitro Drug Permeability.

ABSTRACT: Food additives are chemical substances that are added to processed food to improve its flavor, texture, or appearance. Food additives can inhibit intestinal transporters, such as breast cancer resistance protein (BCRP), multidrug resistance associated protein 2 (MRP2), organic anion transporting polypeptide 2B1 (OATP2B1), and P-glycoprotein (P-gp). This inhibition could potentially affect the absorption of their substrate drugs and cause unwanted food-drug interactions. In this study, 22 food additives were evaluated for their impact on BCRP, MRP2, OATP2B1, and P-gp transport. The inhibition potency toward intestinal transporters was first studied using membrane vesicles and HEK293 cells. In these assays, four food additives (beta-carotene, butylated hydroxytoluene, dodecyl gallate, and oc

SUBMITTER: Suominen L 

PROVIDER: S-EPMC12406256 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature