ERK signaling promotes IKKε expression and oncogenic functions in pancreatic cancer cells in association with TBK1.

ABSTRACT: A variety of cancers utilize RAS-regulated signaling pathways to promote oncogenic phenotypes. A widely studied example is pancreatic cancer, where mutant KRAS signaling leads to activation of MEK (mitogen-activated protein kinase/extracellular signal-regulated kinase [ERK])-ERK and downstream signaling, which promotes oncogenic mechanisms, including cell proliferation. Importantly, ERK inhibitors have shown efficacy in some cancer clinical trials. Previously, others have studied the effects of the related kinases TANK-binding kinase 1 (TBK1) and inhibitor of nuclear factor kappa-B kinase epsilon (IKKε) in pancreatic cancer where they have been shown to promote cell survival. Here, we show that RAS-mitogen-activated protein kinase signaling promotes expression of IKKε through control of pr

SUBMITTER: Graves A 

PROVIDER: S-EPMC12406268 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature