Sidt2 inhibits islet β-cell dedifferentiation by regulating insulin secretion.

ABSTRACT: β-cell dedifferentiation plays an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). SID1 transmembrane family member 2 (Sidt2) is a lysosomal membrane protein known to regulate hepatic steatosis and lipid metabolism. However, its role in pancreatic β-cell dedifferentiation remains unclear. In this study, we found that Sidt2 expression was significantly decreased in diabetic mice and patients, correlating with impaired glucose metabolism. Through in-vitro and in-vivo experiments, we observed that the loss of Sidt2 accelerated β-cell dedifferentiation, as evidenced by an increase in the number of α cells and a marked reduction in key β-cell markers, such as pancreatic and duodenal homeobox 1 (Pdx1), V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), and glu

SUBMITTER: Gu J 

PROVIDER: S-EPMC12406273 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature