Opt1 imports CoA precursors as glutathione mixed disulfides.

ABSTRACT: Pantothenate is a key vitamin for the intracellular biosynthesis of the essential molecule coenzyme A (CoA). Pantothenate can be biosynthesized or is taken up by cells via plasma membrane transporters. In the cell, pantothenate, ATP, and cysteine are required to synthesize CoA via five enzymatic steps. This canonical CoA biosynthesis route is well-studied in various organisms. Alternative routes that begin with the uptake of pantetheine (PanSH) or 4'-phosphopantetheine (PPanSH) as initial CoA precursors also exist. These alternative routes are vital for numerous unicellular organisms and are of interest for treating human diseases caused by defects in the canonical CoA biosynthesis pathway. In contrast to the uptake mechanisms for pantothenate, the cellular uptake mechanisms for PanSH and/

SUBMITTER: Wedman JJ 

PROVIDER: S-EPMC12406275 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature