SLC16A3 as an immunosuppressive Kupffer cell marker predicts poor prognosis in HBV-positive hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is one of the malignant tumors that currently pose a significant threat to human health, with infection by hepatitis B virus (HBV) being a critical risk factor for the development of HCC. It is critical to identify potential molecular targets affecting HBV-positive HCC patients.

Methods

In this study, we comprehensively utilized single-cell sequencing and external transcriptome sequencing databases to further analyze the mechanism of SLC16A3's influence on liver cancer and its microenvironment under different HBV status. Immunohistochemical staining in our clinical cohort was used to analyze the expression difference and influence of SLC16A3 in HCC. At the same time, we confirmed the direct effects of SLC16A3 on HCC cells with differ

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12406350 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature