Global scoring method of Ki67 immunohistochemistry in breast cancer demonstrates improved concordance using real-world multi-institutional data.

ABSTRACT: Ki67 is a broadly available biomarker of proliferation with various approaches to its evaluation in breast cancer. The International Ki67 in Breast Cancer Working Group (IKWG) recommends calculating Ki67 globally across the tumor area, as this method offers high interobserver concordance. These recommendations have been integrated into many international breast cancer guidelines (ASCO, ESMO), yet there is no real-world data on if it improved inter-pathologists and inter-laboratory variability. Here, we present the first real-world data on the variability and impact of Ki67 scores on clinical decision-making in breast cancer when using hotspot scoring and after implementing IKWG global scoring method in clinical practice. We extracted hotspot and global scoring results from 4313 breast canc

SUBMITTER: Boyaci C 

PROVIDER: S-EPMC12406372 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature