Association between neutrophil-to-HDL cholesterol ratio and the risk of gout or hyperuricemia: evidence from NHANES 2007-2018.

ABSTRACT:

Background

Neutrophil-to-HDL-C ratio (NHR) has recently emerged as a composite biomarker integrating lipid metabolism and inflammatory status. Nevertheless, its potential association with the risk of gout or hyperuricemia remains inadequately explored. The present study aimed to examine the possible link between NHR and both conditions.

Methods

This study included 31,117 eligible adults from the 2007-2018 NHANES database in the United States. Participants were categorized into NHR quartiles, and weighted multivariate logistic regression along with restricted cubic spline (RCS) analyses was performed to assess its association with gout and hyperuricemia risk. Subgroup analyses were performed to assess the robustness and heterogeneity of the association across different subpop

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12406440 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature