The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study.

ABSTRACT:

Background

Untargeted metabolomic analysis provides novel insights into the relationship between sodium intake and cardiometabolic risk. This study examined cross-sectional associations between estimated sodium intake and plasma metabolite profiles in a large Swedish cohort.

Methods

This cross-sectional analysis was conducted in the in the SCAPIS cohort (mean age 50-64 years, n = 8,957). Sodium intake was estimated using the Kawasaki formula (est24hNa) from urine samples. Plasma metabolites were measured using ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) (Metabolon Inc^®), identifying 713 metabolites grouped into eight biochemical classes (CC). Principal component analysis (PCA) was conducted for each CC, and the first principal

SUBMITTER: Wuopio J 

PROVIDER: S-EPMC12406461 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature