Comprehensive genomic profiling of over 10,000 advanced solid tumors.

ABSTRACT:

Purpose

To summarize clinically relevant genomic alterations in solid tumor samples from over 10,000 patients.

Methods

Descriptive statistics were used to summarize findings of retrospectively analyzed OncoExTra assay data from solid tumor samples.

Results

The analysis cohort included 11,091 solid tumor samples from 10,768 patients. Therapeutically actionable alterations were present in 92.0% of patient samples. Biomarkers associated with on- or off-label FDA-approved therapies were detected in 29.2% and 28.0% of samples, respectively. The prevalence of hotspot alterations detected at variant allele frequency (VAF) <5% was analyzed among 7,481 samples (67.5%) harboring ≥1 of these events: 13.7% (1,022 of 7,481) had ≥1 alteration detected at VAF <5%, and 9.8% (558 of 5

SUBMITTER: De La O JP 

PROVIDER: S-EPMC12406462 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature