Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy.

ABSTRACT: Hepatic encephalopathy (HE) is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes, particularly in cases of severe liver disease or cirrhosis. Previous studies have reported spatially distributed structural and functional abnormalities related to HE, but the exact relationship between the structural and functional alterations with respect to disease progression remains unclear. In this study, we performed surface-based cortical thickness comparisons and functional connectivity (FC) analyses between three cross-sectional groups: healthy controls (HC, N = 51), patients with minimal hepatic encephalopathy (MHE, N = 50), patients with overt hepatic encephalopathy (OHE,

SUBMITTER: Sha G 

PROVIDER: S-EPMC12406529 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature