Diffusion tractography of kidney by high angular resolution diffusion imaging.

ABSTRACT: Diffusion magnetic resonance imaging (MRI) has been utilized to probe the renal microstructures but investigating the three-dimensional (3D) tubular network still presents significant challenges due to the complicated architecture of kidney. This study aims to assess whether high angular resolution diffusion imaging (HARDI) could improve the reconstruction of 3D tubular architectures. Kidneys from both mice and rats were imaged using 3D diffusion-weighted pulse sequences at 9.4 T. Five healthy mouse kidneys were scanned at an isotropic spatial resolution of 40 μm, with a b value of 1500 s/mm² across 46 diffusion encoding directions. The study employed diffusion tensor imaging (DTI) and generalized Q-sampling imaging (GQI) to examine the tubular orientation distributions a

SUBMITTER: Maharjan S 

PROVIDER: S-EPMC12406531 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature