Low-field, high-gradient NMR shows diffusion contrast consistent with localization or motional averaging of water near surfaces.

ABSTRACT: Nuclear magnetic resonance (NMR) measurements of water diffusion have been extensively used to probe microstructure in porous materials, such as biological tissue, however primarily using pulsed gradient spin echo (PGSE) methods. Low-field single-sided NMR systems have built-in static gradients (SG) much stronger than typical PGSE maximum gradient strengths, which allows for the signal attenuation at extremely high b-values to be explored. Here, we perform SG spin echo (SGSE) and SG stimulated echo (SGSTE) diffusion measurements on biological cells, tissues, and gels. Measurements on fixed and live neonatal mouse spinal cord, lobster ventral nerve cord, and starved yeast cells all show multiexponential signal attenuation on a scale of b with significant signal fractions obser

SUBMITTER: Williamson NH 

PROVIDER: S-EPMC12406550 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature