NMR relaxation and diffusion studies to probe the motional dynamics of risperidone within PLGA microsphere.

ABSTRACT: The present study aims to investigate the motional dynamics of risperidone within polylactic co-glycolic acid (PLGA) microsphere by employing solution state ¹H and ¹⁹F nuclear magnetic resonance (NMR) measurements. Risperidone, a second-generation fluorinated antipsychotic drug used for the treatment of schizophrenia is commercially marketed as PLGA microsphere formulation resulting in prolonged release of the drug in solution. Although the current trend in the pharmaceutical market is to develop drug formulation with long-acting release (LAR) products, complete physicochemical characterization of such formulations are scarce. Especially the effects of microsphere encapsulation on the motional properties and diffusion behavior of the drugs are not discussed adequately

SUBMITTER: Kumar D 

PROVIDER: S-EPMC12406595 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature