Low isavuconazole trough levels in critically ill patients with and without extracorporeal membrane oxygenation.

ABSTRACT: Data on isavuconazole exposure in critically ill patients and particularly during extracorporeal membrane oxygenation (ECMO) are scarce, and therapeutic drug monitoring is not routinely performed. Critically ill patients admitted to a tertiary ECMO referral center from October 2017 to August 2024 with documented isavuconazole trough levels were retrospectively analyzed. First, measured isavuconazole trough blood levels and the occurrence of dose adjustments were analyzed in patients with and without ECMO support. Fifty-three adult patients were included, of whom 11 (21%) patients were on ECMO support at the first isavuconazole trough level measurement. Median isavuconazole trough level was overall 1.4 (interquartile range [IQR] 0.9-2.5) mg/L and did not differ between ECMO (1.3 [IQR 0.9-1.

SUBMITTER: Erlebach R 

PROVIDER: S-EPMC12406667 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature