Emergence of carbapenem-resistant <i>Acinetobacter baumannii</i> clonal complex 2 in multiple hospitals in Sao Paulo state, Brazil.

ABSTRACT: Carbapenem-resistant Acinetobacter baumannii (CRAB) is a common pathogen prevalent in Brazilian hospitals. Worldwide, dissemination of CRAB is associated with the Clonal Complex 2 (CC2); in South America, however, CC1, 15, 25, and 79 are the most prevalent clones. In July 2020, our reference laboratory received the first CC2 isolates from a COVID-19 hospital, and, in the following months, this clone was detected in 15 other Brazilian institutions. To understand the clonal structure of this emerging pathogen, we characterize 89 isolates by whole-genome sequencing and antimicrobial susceptibility testing. Disk diffusion revealed resistance to all beta-lactams, aminoglycosides, fluoroquinolones, folate pathway antagonists, and tetracyclines, but susceptibility to polymyxin B. Resistome

SUBMITTER: Yamada AY 

PROVIDER: S-EPMC12406670 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature