Clinical pharmacokinetics of metronidazole: a systematic review and meta-analysis.

ABSTRACT: Metronidazole (MTZ) is used in various clinical settings; however, its pharmacokinetics may vary across patient populations due to physiological and pathological differences. Understanding these variations is important for personalized dosing and optimization of therapeutic outcomes. This study aimed to systematically review clinical pharmacokinetic studies of MTZ and perform a meta-analysis of the area under the concentration-time curve (AUC). AUC was selected for meta-analysis as it provides a direct and comprehensive measure of total drug exposure over time, facilitating standardized comparisons across populations. Four databases, including PubMed, ScienceDirect, Cochrane Library, and Google Scholar, were screened for pharmacokinetic studies on MTZ using systematic search strategies unt

SUBMITTER: Shahzad I 

PROVIDER: S-EPMC12406673 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature