¹H and ³¹P MRS Interleaved With High Time Resolution Reveals Closely Matching Creatine CH₂ and PCr Dynamics During Exercise.

ABSTRACT: The rate of intramuscular phosphocreatine (PCr) depletion and recovery in response to exercise estimated from ³¹P MRS is an established measure for oxidative capacity. The creatine CH₂ resonance in ¹H MRS is known to exhibit a similar pattern. So far, repeating the exercise for consecutive ¹H and ³¹P experiments posed limitations on the interpretation. Acquiring both datasets in a single time-resolved experiment allows for direct quantitative comparison of creatine-CH₂ and PCr kinetics. This can help answer to what extent creatine-CH₂ mimics PCr dynamics and provide data on the visibility of myocellular creatine. Twenty-seven volunteers, assigned to a group with lower BMI (n = 16, BMI = 22.1 ± 3.2 kg/m²

SUBMITTER: Klepochova R 

PROVIDER: S-EPMC12406759 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature