Association of metformin treatment with changes in metal dynamics in individuals with type 2 diabetes.

ABSTRACT:

Introduction

The metal-chelating activity of metformin, which has long been known but of unclear clinical relevance, has recently been implicated in the pleiotropic effects, including antitumorigenic and anti-inflammatory actions, of the drug. However, whether metformin actually influences metal dynamics in humans has remained unknown. We here investigate whether metformin influences serum metal levels in individuals with type 2 diabetes.

Research design and methods

In this cross-sectional study, individuals with type 2 diabetes treated or not treated with metformin for at least 6 months were recruited. The primary outcome was the difference in serum copper concentration between metformin users and non-users. Secondary outcomes included differences in serum levels of iron, z

SUBMITTER: Otowa-Suematsu N 

PROVIDER: S-EPMC12406903 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature