Mapping functional hemodynamic and metabolic responses to dementia: a broadband spectroscopy pilot study.

ABSTRACT:

Significance

Broadband near-infrared spectroscopy (bNIRS) can simultaneously monitor several chromophores, including the oxidative state of cytochrome c-oxidase (oxCCO), an oxygen metabolism biomarker, the activity of which is altered in Alzheimer's disease. Being a portable and noninvasive neuromonitoring technique, bNIRS could provide accessibility to brain-specific biomarkers and aid in the dementia diagnostic pathway.

Aim

We use bNIRS-recorded functional hemodynamic and oxCCO changes to assess their relevance in Alzheimer's disease diagnosis.

Approach

Using a visual stimulus paradigm, we recorded functional changes in oxy-, deoxy-hemoglobin and oxCCO in three similarly aged cohorts: healthy controls ( n=5 ), individuals with mild cognitive impairment ( n=7 ), and

SUBMITTER: Acharya D 

PROVIDER: S-EPMC12407020 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature