Genetic variants linked to type 2 diabetes in CDKN1B and TCF7L2 influence survival outcomes in metastatic colorectal cancer.

ABSTRACT: Evidence suggests that metastatic colorectal cancer patients with type 2 diabetes (T2D) experience a poorer prognosis in contrast to their non-diabetic counterparts. Considering the multifactorial genetic nature of colon cancer development, we examined whether gene polymorphisms associated with T2D could affect the clinical outcome of metastatic colon cancer. Using in silico analysis, we evaluated gene variants linked to both T2D and colon cancer utilizing data from The Cancer Genome Atlas (TCGA). Subsequently, we assessed the prognostic relevance of polymorphisms in CCND2, CDKN1B, CDKN2A, CDKN2B, EML4, HNF1A, ID3, IGF1, IGF1R, IGF2, INHBA, INSR, IRS1, IRS2, and TCF7L2 in a cohort of 99 consecutive metastatic non-diabetic colon cancer patients with favorable clinical conditions. Primary co

SUBMITTER: Ruggiero R 

PROVIDER: S-EPMC12407037 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature