Pulmonary toxicity in children, adolescents, and young adults with testicular germ cell tumors: A population-based retrospective matched cohort study.

ABSTRACT: While testicular germ cell tumors (TGCT) are highly curable, survivors experience toxicities. Pulmonary outcomes post-TGCT are not well understood, particularly among children, adolescents, and young adults (CAYA). Using provincial cancer registries, we identified all CAYA (aged 11-21 years) diagnosed with a TGCT from 1992 to 2021 in Ontario, Canada, and matched them (1:5) to general population males (controls). We linked CAYA to health administrative databases to identify pulmonary disease and pulmonary disease healthcare visits (PDV) and classified PDV severity as low (outpatient family physician/pediatrician), medium (outpatient respirologist/internist), or high (hospitalization/emergency department). We assessed acute (<5 years from diagnosis) and late (≥5 years after diagnosis) toxici

SUBMITTER: Ajaj R 

PROVIDER: S-EPMC12407061 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature