Microenvironment-driven transformable self-assembly nanoplatform enables spatiotemporal remodeling for rheumatoid arthritis therapy.

ABSTRACT: The aberrant vasculature within the inflamed joint cavity of rheumatoid arthritis (RA) not only exacerbates joint pathology but also restricts the effective delivery of therapeutic drugs. Herein, we propose a strategy that involves the rapid and sustained vasculature repair alongside microenvironment-driven drug delivery to achieve multifaceted RA management. The transformable, self-assembling nanoplatform specifically accumulates in the inflamed joint cavity guided by a vascular targeting peptide (STP). Subsequently, STP detaches and undergoes shape transformation, forming nanofibers on the vascular endothelium, which serve as a rapid-acting physical barrier in the short term and facilitate sustained vascular normalization in the long term. Concurrently, the remaining nanoparticles underg

SUBMITTER: Hu C 

PROVIDER: S-EPMC12407069 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature