Path integration impairments reveal early cognitive changes in subjective cognitive decline.

ABSTRACT: Path integration, the ability to track one's position using self-motion cues, is critically dependent on the grid cell network in the entorhinal cortex, a region vulnerable to early Alzheimer's disease pathology. In this study, we examined path integration performance in individuals with subjective cognitive decline (SCD), a group at increased risk for Alzheimer's disease, and healthy controls using an immersive virtual reality task. We developed a Bayesian computational model to decompose path integration errors into distinct components. SCD participants exhibited significantly higher path integration error, primarily driven by increased memory leak, while other modeling-derived error sources, such as velocity gain, sensory, and reporting noise, remained comparable across groups. Our find

SUBMITTER: Segen V 

PROVIDER: S-EPMC12407072 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature