Rad51, Rad54, and ZMM proteins antagonize the mismatch repair system to promote fertility of budding yeast intraspecies hybrid zygotes.

ABSTRACT: Rad51 and meiosis-specific Dmc1 catalyze homologous recombination (HR) between maternal and paternal chromosomes during meiosis in many sexual eukaryotes, generating three interhomolog (IH) recombination products: non-crossovers (NCOs), class I interference-sensitive crossovers (COs), and class II non-interfering COs. CO interference suppresses relatively close CO formation. Some COs form chiasmata, which physically connect homologous chromosomes and ensure proper chromosome segregation during meiosis I. Meiosis is highly relevant to speciation, with the mismatch repair (MMR) system believed to prevent IH recombination, leading to post-zygotic isolation between closely related species. We report that several Saccharomyces cerevisiae homologous recombination proteins exhibit anti-MMR activi

SUBMITTER: Hung YL 

PROVIDER: S-EPMC12407102 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature