Gompertz Law-Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks.

ABSTRACT: Biological age reflects actual ageing and overall health, but current ageing clocks are often complex and difficult to interpret, which limits their clinical application. This study introduces a Gompertz law-based biological age (GOLD BioAge) model designed to simplify the assessment of ageing. We calculated GOLD BioAge using clinical biomarkers and found significant associations between the difference from chronological age (BioAgeDiff) and the risks of morbidity and mortality in the NHANES and UK Biobank. Using proteomics and metabolomics data, we developed GOLD ProtAge and MetAge, which outperformed the clinical biomarker models in predicting mortality and chronic disease risk in UK Biobank. Benchmark analyses demonstrated that the models outperformed common ageing clocks in predicting

SUBMITTER: Hao M 

PROVIDER: S-EPMC12407260 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature