Toward the Clinical Translation of Implantable Brain-Computer Interfaces for Motor Impairment: Research Trends and Outcome Measures.

ABSTRACT: Implantable brain-computer interfaces (iBCIs) decode neural signals to control external effectors, offering potential to restore function in individuals with severe motor impairments, such as loss of limb function or speech. This systematic review examines the evolution of iBCI research and key bottlenecks to clinical translation, particularly the absence of standardized, clinically meaningful outcome measures. A comprehensive search of MEDLINE, Embase, and CINAHL identifies 112 studies, nearly half (49.1%) published since 2020. Eighty unique iBCI participants were identified, providing the most up-to-date estimate of global users. Research remains concentrated in the United States (83%), with growing contributions from Europe, China, and Australia. Electrocorticography (ECoG)-based device

SUBMITTER: Dohle E 

PROVIDER: S-EPMC12407270 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature