Anti-AHNAK1 Antibodies Are a Novel Diagnostic Biomarker for Systemic Lupus Erythematosus.

ABSTRACT: Calcium signaling is essential for the proper function of immune cells. Recent studies have shown that the scaffold protein, AHNAK1, is important for efficient calcium signaling and NFAT activation in T cells through its ability to properly localize calcium ion (Ca²⁺) channels at the plasma membrane. Interestingly, both T cells and B cells of systemic lupus erythematosus exhibit activation signaling anomalies with dysregulated Ca²⁺ response, and enhanced Ca²⁺ signaling has emerged as a target for treatment with SLE. Therefore, we hypothesized SLE patients may have autoantibodies (Abs) against AHNAK1 because anti-AHNAK1 antibodies possibly are able to interfere with Ca²⁺ signaling through binding to AHNAK1, subsequently resulting in aberrant T cel

SUBMITTER: Matushita Y 

PROVIDER: S-EPMC12407309 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature