Cadinapyridine sesquiterpene alkaloids from Artemisia annua and in vitro cytotoxicity and antiplasmodial activities.

ABSTRACT: Artemisia annua L. (A. annua) is a medicinal herb that has been used for the last two millennia to treat various diseases. In African countries, teas prepared from cultivated A. annua have been used to treat malaria for the past three decades. In another work, our team investigated the antiplasmodial efficacy of these traditional preparations using a Liquid-Chromatography-Mass Spectrometry metabolomic approach on various teas prepared from different batches of A. annua collected in Benin and in France and highlighted an original nitrogenous compound. The present work aimed to isolate and characterize its structure. Therefore we describe the fractionation of an alkaloid extract from a Beninese sample of the plant's aerial parts led to the isolation of two previously undescribed alkaloids, a

SUBMITTER: Fabre N 

PROVIDER: S-EPMC12407398 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature