New insights into the molecular biology of Alzheimer's-like cerebral amyloidosis achieved through multi-omics approaches.

ABSTRACT:

Background

One of the neuropathologic hallmarks of Alzheimer's disease (AD) is amyloid plaques composed of fibrillar amyloid beta (Aβ) that accumulate in the hippocampus and cerebral cortex. The identification of molecular changes and interactions associated with Aβ-dependent cerebral amyloidosis is a need in the field. We hypothesize that structured datasets linking proteins to differentially abundant metabolites may provide an indirect but effective means of elucidating the processes and functions in which these metabolites are involved. The goal of this study was to identify core network modules related to AD-like cerebral amyloidosis to provide new insights into the molecular underpinnings of this brain disorder potentially associated with diet and microbiota modulation.

Met

SUBMITTER: Campanelli L 

PROVIDER: S-EPMC12407441 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature