SARS-CoV-2 antibody and neutralization dynamics among persons with natural- and vaccine-induced exposures.

ABSTRACT: Previous SARS-CoV-2 research indicates that antibody levels and corresponding neutralization potential increase with additional exposures (comprising vaccination or infection), and that hybrid immunity resulting from combined vaccination and natural infection is more robust than either alone. However, it is unclear whether or how antibody levels increase or eventually plateau with repeated exposures and how SARS-CoV-2 exposure differs by sex or other demographic factors. Research regarding the association of antibody production with neutralization potential is also limited. We conducted this analysis within the RESPIRA population-based cohort in Costa Rica to investigate relationships between antibody levels and neutralization potential at increasing exposure levels. We examined immunologi

SUBMITTER: Semancik CS 

PROVIDER: S-EPMC12407447 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature