Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable Proteins.

ABSTRACT:

Objectives

To construct multi-trait polygenic scores (PRS) predicting chronic obstructive pulmonary disease (COPD) and exacerbations, validate their performance in diverse cohorts, and identify PRS-related proteins for potential therapeutic targeting.

Design

Prospective cohort studies.

Setting

Genetic Epidemiology of COPD (COPDGene; 2007-present), Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE; 2005-2008), Mass General Brigham Biobank (MGBB; 2010-present), All of Us (2016-present), and UK Biobank (UKB; 2006-present).

Participants

6,647 non-Hispanic White (NHW) and 2,466 African American (AA) participants from COPDGene; 1,858 participants from ECLIPSE; 118,566 from All of Us; 15,142 from MGBB with genetic data. 5,173 COPDGe

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12407601 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature