Plasma metabolic landscape unveils key regulators of leukemia subtype progression.

ABSTRACT:

Background

Leukemia is driven by metabolic reprogramming, yet the specific causal roles of plasma metabolites in distinct leukemia subtypes remain unclear.

Methods

This study employed Mendelian randomization (MR) to explore potential causal links between 690 plasma metabolites (and 143 metabolite ratios) and four leukemia subtypes: ALL, AML, CLL, and CML. Genetic variants from genome-wide association studies served as instrumental variables. Multiple MR approaches, including IVW, MR-Egger, and Weighted Median, along with sensitivity analyses, were applied to ensure robust results.

Results

Our findings revealed subtype-specific metabolite associations. In ALL, metabolites such as 3-Hydroxyisobutyrate and γ-Glutamylglutamate showed positive associations, while Phosphoch

SUBMITTER: Liang C 

PROVIDER: S-EPMC12407637 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature