Carnosinylation of Cardiac Antigens Attenuates Immunogenic Responses and Improves Function in Failing Hearts.

ABSTRACT:

Objective

To investigate the effects of carnosine on heart failure and to examine whether this is associated with reduced immunogenicity of oxidatively-generated aldehyde modified proteins.

Background

Heart failure is associated with the accumulation of lipid derived aldehydes that form immunogenic protein adducts. However, the pathological impact of these aldehydes and aldehyde-modified proteins in heart failure has not been assessed. Histidyl dipeptides, such as carnosine found in the heart, bind to aldehydes, and their protein adducts. However, the effects of carnosine on heart failure or the antigenicity of aldehyde modified proteins have not been studied.

Methods

Male, wild type C57BL/6J mice were subjected to either sham or transverse aortic constriction (TAC) s

SUBMITTER: Doelling B 

PROVIDER: S-EPMC12407691 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature