A deep, quantitative lipid atlas of extracellular vesicles across multiple cell lines.

ABSTRACT: Extracellular vesicles (EVs) are subcellular particles surrounded by a lipid bilayer membrane and incorporating various additional biomolecules derived from their donor cell. In many disease contexts circulating EVs have received increasing scientific attention due to their potential diagnostic and prognostic value. Additionally, EVs have been ascribed multiple biological functions, ranging from cellular waste disposal to sophisticated, intercellular communication. Consequently, EVs involved in pathological processes may represent therapeutic targets, whereas EV-based therapeutics are being developed for targeted delivery of molecular cargoes in vivo. Detailed knowledge of the molecular content of natural EVs derived from diverse cellular origins is crucial to identify biomarkers, dissect

SUBMITTER: Acari A 

PROVIDER: S-EPMC12407696 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature