Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues.

ABSTRACT: The Tabula Sapiens is a reference human cell atlas containing single cell transcriptomic data from more than two dozen organs and tissues. Here we report Tabula Sapiens 2.0 which includes data from nine new donors, doubles the number of cells in Tabula Sapiens, and adds four new tissues. This new data includes four donors with multiple organs contributed, thus providing a unique data set in which genetic background, age, and epigenetic effects are controlled for. We analyzed the combined Tabula Sapiens data for expression of transcription factors, thereby providing putative cell type specificity for nearly every human transcription factor and as well as new insights into their regulatory roles. We analyzed the molecular phenotypes of senescent cells across the entire data set, providing ne

SUBMITTER: Tabula Sapiens Consortium 

PROVIDER: S-EPMC12407789 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature