Affinity Maturation and Light-Chain-Mediated Paratope Diversification Anticipate Viral Evolution.

ABSTRACT: A key goal of vaccinology is to train the immune system to combat current pathogens while simultaneously preparing it for future evolved variants. Understanding factors contributing to anticipatory breadth, wherein affinity maturation against an ancestral strain yields neutralization capacity against evolved variants, is therefore of great importance. Here, we investigated the mechanism of anticipatory breadth development in a public antibody family targeting the functionally restricted ACE2 binding site on SARS-CoV-2. IGHV3-53/66 antibodies isolated from memory B cells of infection-naïve individuals vaccinated with the ancestral Wuhan-strain mRNA vaccine frequently neutralized evolved Omicron variants and contained several hallmark mutations previously shown to enhance neutralization brea

SUBMITTER: Dingus J 

PROVIDER: S-EPMC12407817 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature