RNA binding by ADARs prevents RNA interference from attacking self-produced dsRNA.

ABSTRACT: The ability of an organism to identify self and foreign RNA is central to eliciting an immune response in times of need while avoiding autoimmunity. As viral pathogens typically employ double-stranded RNA (dsRNA), host identification, modulation, and response to dsRNA is key. However, dsRNA is also abundant in host transcriptomes, raising the question of how these molecules can be differentiated. Two host pathways that regulate dsRNA are A-to-I RNA editing by adenosine deaminases (ADARs), and RNA interference (RNAi). Both mechanisms are important for normal organism development and function by regulating gene expression. Herein, we studied the structure and amount of siRNAs at editing sites and the ability of ADARs to prevent exogenous RNAi using the model organism, Caenorhabditis elega

SUBMITTER: Ganem NS 

PROVIDER: S-EPMC12407824 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature