Brain morphology network alterations in adolescents with autism spectrum disorder: a sex-stratified study.

ABSTRACT:

Background

One of the most persistent questions in autism research is why males are more consistently diagnosed than females. Neuroimaging studies have sought to understand this disparity by examining sex differences, primarily through functional and structural connectivity. However, much less is known about how brain networks are organized in autism from a morphological perspective, and how this organization may help explain its sex-related characteristics. This study aimed to elucidate sex-specific alterations in morphology-based connectivity among adolescents with autism spectrum disorder (ASD).

Methods

T1-weighted MRI scans from 337 individuals (181 with ASD; 162 females in total), aged 8-18 years, were preprocessed using FreeSurfer to extract five morphological features

SUBMITTER: Safari N 

PROVIDER: S-EPMC12407832 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature