Clinical representativeness of pivotal trials for T-cell engagers in relapsed/refractory follicular lymphoma.

ABSTRACT:

Aim

To characterize trial populations of T-cell-engaging therapies, including bispecific antibodies and chimeric antigen receptor T-cell therapies, for relapsed/refractory (R/R) follicular lymphoma (FL) after ≥ 2 systemic therapies and the extent to which they represent real-world R/R FL populations.

Methods

Inclusion/exclusion criteria and baseline characteristics were compared descriptively for EPCORE NHL-1 (epcoritamab, N = 128), GO29781 (mosunetuzumab, N = 90), ELARA (tisagenlecleucel [tisa-cel], N = 97), and ZUMA-5 (axicabtagene ciloleucel [axi-cel], N = 124). Real-world data from the COTA Healthcare (New York, NY) and Optum Market Clarity (Eden Prairie, MN) databases contextualized the clinical representativeness of trial populations.

Results

The epcoritamab tri

SUBMITTER: Ding Z 

PROVIDER: S-EPMC12407842 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature