Precise Extraction of Neural Motifs Reveals Multiscale, Parallel Encoding Schemes in Auditory Cortex.

ABSTRACT: Neural population activity is often stereotyped into recurring activity patterns, i.e., neural motifs, which can be seen as the fundamental building blocks in sensory processing and cognition. In this work we study the codes carried by such neural motifs in primary auditory cortex A1, and analyze how they build on and complement traditional views of single-unit coding. In particular, we study, using two-photon calcium imaging (CI), how activity in A1 differentially represents both sensory stimuli and task and behavioral variables in each of the parallel single neuron and population motif scales. While CI enables the study of neural motifs by capturing the activity of large neural populations, identifying motifs in CI is hampered by the temporal imprecision of current motif-detection algori

SUBMITTER: Xiang L 

PROVIDER: S-EPMC12407935 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature