GPCR endocytosis rewires neuronal gene expression and cellular architecture.

ABSTRACT: In the brain, G protein-coupled receptors (GPCRs) regulate neuronal excitability, synaptic transmission, and behavior by engaging transcriptional and translational programs that produce enduring changes in cellular function and architecture. However, the molecular mechanisms that couple GPCR activation to these adaptations remain poorly understood. Here, we demonstrate that the beta-adrenergic receptor (β2AR), a mediator of noradrenaline in the central nervous system, remodels neuronal morphology through compartmentalized signaling pathways that orchestrate distinct layers of gene regulation. Following stimulation, β2ARs remain active on endosomes, and their intracellular signaling promotes dendritic growth and synapse formation. These structural effects are driven by two coordinated regul

SUBMITTER: Hall KL 

PROVIDER: S-EPMC12407939 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature