Cardioprotective effects of AMPK activation in H1N1 influenza virus infection.

ABSTRACT: Cardiac complications are among the most common and severe extrapulmonary manifestations of influenza virus infection, yet they are rarely recapitulated in mouse models without immunodeficiency. We found that influenza virus A/California/04/2009 (H1N1) carrying a mouse-adaptive amino acid substitution in the PB2 protein (E158A) disseminates to the heart in WT C57BL/6 mice, where it induces inflammation, electrical dysfunction, and fibrotic remodeling. Influenza virus-infected heart tissue was significantly altered in mitochondrial metabolism, extracellular matrix, circadian rhythm, and immunity pathways. Particularly striking was activation of gene expression downstream of the mitochondrial biogenesis-promoting AMPK/PGC-1α axis, which occurred late in infection but failed to reverse the re

SUBMITTER: Leumi S 

PROVIDER: S-EPMC12407972 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature